 |
|
 |
|
|
|
|
| |
Research activities
in the COE program |
 |
|
|
|
|
| |
Mechanisms for the maintaining of "stemness"
The quiescent state is thought to be an indispensable
property for the maintenance of hematopoietic stem cells
(HSCs). The interaction of HSCs with their particular
microenvironment, known as the stem cell niche, is critical
for adult hematopoiesis in the bone marrow (BM). HSCs
expressing the receptor tyrosine kinase Tie2 are quiescent
and anti-apoptotic, and comprise a large proportion of
side-population (SP) HSCs, which are surrounded by bone-lining
osteoblasts in the adult bone marrow. We suggest that
the Ang- 1/Tie2 signaling pathway plays a critical role
in recruitment of stem cells to the BM niche, and maintains
these cells in a quiescent state. |
| |
|
| |
 |
| |
|
|
|
|
