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Research activities
in the COE program |
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Clarification of the immunopathological
mechanism of an autoimmune skin disease,pemphigus, and
development of disease-specific therapeutic approaches
The goal of our research group is to clarify the immunopathological
mechanism of autoimmune skin disease, pemphigus, and to
develop disease-specific therapeutic approaches with less
severe side effects. Using the pemphigus mouse model,
which has been developed by a unique approach using autoantigen
knockout mice, as well as patients specimens, we are attempting
to understand the tolerance mechanism against pemphigus
autoantigen desmogleins at the B cell and T cell level.
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